November 6, 2018 @ 10:00 am – 11:00 am

Jinjian Zheng, Principal Scientist at Merck & Co., Inc., will discuss the use of gas chromatography with vacuum ultraviolet detection (GC-VUV) in the pharmaceutical industry.

Flame ionization and thermal conductivity detectors for gas chromatography have limitations in the types of compounds they can detect and lack the qualitative spectral information. VUV detectors can detect almost any compound except for hydrogen and some noble gases along with spectral information comparable to a photodiode array detector for liquid chromatography. The versatility and qualitative spectral information offered by GCVUV offers potential for substantial improvements on conventional gas chromatography (GC) analysis. The adoption of GC-VUV in the pharmaceutical industry will be led by its uses in the development of methods for impurity profiling, stability indicating, or the analysis of complex reaction mixtures.

Key Learning Objectives:

  • An overview of traditional and current methods to address the many challenges in pharmaceutical analysis
  • Limitations of traditional methods including GC-FID, TCD and ECD in comparison to the industry disrupter GC-VUV
  • The advantages that GC-VUV presents in identifying peaks and assessing their purity