VUV spectroscopy provides a method for residual solvent characterization that results in reduction of chromatography runtimes by 5X or greater. In addition, different solvent types (Classes 1–3 and others) can be combined into individual compressed analyses for further sample throughput gains. Water determination by GC-VUV delivers a more accurate and precise method than Karl Fischer while not requiring the use toxic reagents.
Known advantages of VUV Spectroscopy
- The ability to compress chromatography runtimes by 5X or greater
- The capability of combining different solvent classes and types (Class 1–3 and others of interest) into individual compressed analyses.
- GC-VUV offers a more precise and user friendly method for water determination
- Co-eluting impurities including isomers can be analyzed without need the for chromatographic baseline resolution
- Instrumentation and software is designed for scaling from R&D to production
- Intuitive data processing workflow and software automation remove analytical complexity
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Analysis of Residual Solvents in Pharmaceutical Excipients and Products with Static Headspace – Gas Chromatography – Vacuum Ultraviolet Absorbance Spectroscopy
Lindsey Shear-Laude describes how residual solvents determination in pharmaceutical products by GC-VUV and automated headspace sampling results in >5X shorter chromatography runtimes and allows the combination of multiple solvents (Class 1, 2, and others) into a single analysis.
View the follow-up webinar hosted by GERSTEL to get additional details about the analytical solution provided when GC-VUV is combined with the GERSTEL automated headspace Multi-Purpose Sampler (MPS).
Shining a new light in gas chromatography and streaming gas applications.
Everything absorbs strongly in the VUV spectrum. Compounds can be unambiguously identified and quantitated in a variety of applications including oil & gas, forensics, fragrances & flavors, petrochemical, environmental, and life science. VUV detectors provide unmatched selectivity of isomers and co-eluting analytes without the need for chromatographic baseline resolution. Unlike legacy detection methods, VUV spectroscopy allows for more automated analysis with lower risk of errors, shorter chromatography run times, and higher analytical throughput.
- Universal, yet selective detector with very sensitive spectral response
- Easy deconvolution and quantitation of co‑eluting analytes
- Robust technology with no reliance on vacuum pumps
- No calibration required – 1st principle detection technique provides a predictable linear response
- Complements mass spectrometry by fully characterizing isomers and compounds with low mass quant ions
Class 1 Residual Solvents
Class 2 Residual Solvents
Class 2 Residual Solvents
Class 3 Residual Solvents
This Dedicated Dialogue interview with Jinjian Zheng of Merck, Inc. provides his perspective on the application of GC-VUV capabilities in pharmaceutical analysis. The adoption of GC-VUV in the pharmaceutical industry will grow as it is used for, "...development of methods for impurity profiling, stability indicating, and the analysis of complex reaction mixtures."
Coeluting Peaks and VUV Absorbance Spectra – When a Little Means a LotJack Cochran, VUV Analytics
Jack Cochran, VUV Analytics
As a gas chromatographer using MS the coeluting-isomer problem didn’t bother me too much, as it allowed me to practice the art of separation. Inevitably though, critical compound separation leads to undesirable, longer GC run times, which brings us back to VUV and its uniqueness.
The VGA-101 is a next generation universal detector for GC with extended wavelength and higher allowable operating temperatures. It is intended to simplify complex applications with advanced capabilities including complete isomer identification, shorter GC run times, and resolution of co-eluting peaks.
VUV en Vogue – The Analytical ScientistThe Analytical Scientist
“The VUV detector has proven itself with the ability to distinguish olefins and aromatics from aliphatics – that’s a killer application given the complexity and time involved using any other technique. The VUV detector’s ability to perform a more accurate and much more robust PIONA analysis is an important milestone in its ongoing success.”
Bill Winniford, Fellow
Bill Winniford, Fellow, The Dow Chemical Company, Houston, Texas, USA
“VUV spectroscopy adds a dimension that is complementary to mass spectrometry, offering selectivity that is difficult to otherwise obtain.”
Hans-Gerd Janssen, Professor and Science Leader
Hans-Gerd Janssen, Professor, University of Amsterdam, and Science leader, Unilever Research Vlaardingen, the Netherlands
“One of the main advantages of VUV detection for us appeared to be the ability to gain more specific molecular information…co-elutions that we know exist but cannot be identified with FID can be unraveled.”
Pierre Giusti, Molecular Separation & Identification Service Manager, and Gaelle Jousset, Gas Chromatography Laboratory Manager
Pierre Giusti, Molecular Separation & Identification Service Manager, and Gaelle Jousset, Gas Chromatography Laboratory Manager, Research & Development, TOTAL Refining & Chemicals, Normandy, France
“The VUV detector will be used as a universal, calibration-free tool that provides the relative quantitative values of distinct molecules in mixtures in a rapid manner.”
Luigi Mondello, Chair of ISCC and GCxGC Conference in Riva del Garda, and Professor
Luigi Mondello, Chair of ISCC and GCxGC Conference in Riva del Garda, and Professor, University of Messina, Italy
“One thing that I really like about VUV is that it can be considered a universal detector but with the advantage of being familiar to us. We all used UV spectrometers in school.”
Nicholas Snow, Professor
Nicholas Snow, Professor, Seton Hall University, New Jersey, USA
“Eliminates ionization inefficiencies that are encountered in mass spectrometry analysis."
Mark R. Emmett, Ph.D.
Mark R. Emmett, Ph.D. Professor, The University of Texas Medical Branch Galveston, UTMB Cancer Research Center
“An amazingly simple concept extended into a powerful spectral region."
Tim Hossain, Ph.D.
Tim Hossain, Ph.D. Chief Scientist, Cerium Laboratories
“The VUV detector is a powerful new tool in the GC toolbox."
Kevin A. Schug, Ph.D.
Kevin A. Schug, Ph.D. Professor & Shimadzu Distinguished Professor of Analytical Chemistry, The University of Texas at Arlington