VUV spectroscopy has unique capabilities that address many of the challenges inherent to gas chromatographic separation and detection. VUV light probes electronic transitions that are unique to individual compound structure. VUV spectral fingerprints are used to differentiate closely related compounds, including structural isomers. GC runtimes can be significantly reduced through flow rate enhanced chromatographic compression and by resolving co-elution with VUV spectral deconvolution. GC-VUV data is both qualitative and quantitative, reducing the burden of multiple detector approaches to fully characterize sample analytes. The simplicity of VUV data and the ability to automate compound class analysis results in a detector that is suitable for both R&D and production settings.