VUV Analytics

Analysis of Residual Solvents in Pharmaceutical Excipients and Products with Static Headspace – Gas Chromatography – Vacuum Ultraviolet Absorbance Spectroscopy

Lindsey Shear-Laude describes how residual solvents determination in pharmaceutical products by GC-VUV and automated headspace sampling results in >5X shorter chromatography runtimes and allows the combination of multiple solvents (Class 1, 2, and others) into a single analysis.

View the follow-up webinar hosted by GERSTEL to get additional details about the analytical solution provided when GC-VUV is combined with the GERSTEL automated headspace Multi-Purpose Sampler (MPS).

View Webinar

“The VUV detector has proven itself with the ability to distinguish olefins and aromatics from aliphatics – that’s a killer application given the complexity and time involved using any other technique. The VUV detector’s ability to perform a more accurate and much more robust PIONA analysis is an important milestone in its ongoing success.”
Bill Winniford, Fellow
Bill Winniford, Fellow, The Dow Chemical Company, Houston, Texas, USA
“VUV spectroscopy adds a dimension that is complementary to mass spectrometry, offering selectivity that is difficult to otherwise obtain.”
Hans-Gerd Janssen, Professor and Science Leader
Hans-Gerd Janssen, Professor, University of Amsterdam, and Science leader, Unilever Research Vlaardingen, the Netherlands
“One of the main advantages of VUV detection for us appeared to be the ability to gain more specific molecular information…co-elutions that we know exist but cannot be identified with FID can be unraveled.”
Pierre Giusti, Molecular Separation & Identification Service Manager, and Gaelle Jousset, Gas Chromatography Laboratory Manager
Pierre Giusti, Molecular Separation & Identification Service Manager, and Gaelle Jousset, Gas Chromatography Laboratory Manager, Research & Development, TOTAL Refining & Chemicals, Normandy, France
“The VUV detector will be used as a universal, calibration-free tool that provides the relative quantitative values of distinct molecules in mixtures in a rapid manner.”
Luigi Mondello, Chair of ISCC and GCxGC Conference in Riva del Garda, and Professor
Luigi Mondello, Chair of ISCC and GCxGC Conference in Riva del Garda, and Professor, University of Messina, Italy
“One thing that I really like about VUV is that it can be considered a universal detector but with the advantage of being familiar to us. We all used UV spectrometers in school.”
Nicholas Snow, Professor
Nicholas Snow, Professor, Seton Hall University, New Jersey, USA
“Eliminates ionization inefficiencies that are encountered in mass spectrometry analysis."
Mark R. Emmett, Ph.D.
Mark R. Emmett, Ph.D. Professor, The University of Texas Medical Branch Galveston, UTMB Cancer Research Center
“An amazingly simple concept extended into a powerful spectral region."
Tim Hossain, Ph.D.
Tim Hossain, Ph.D. Chief Scientist, Cerium Laboratories
“The VUV detector is a powerful new tool in the GC toolbox."
Kevin A. Schug, Ph.D.
Kevin A. Schug, Ph.D. Professor & Shimadzu Distinguished Professor of Analytical Chemistry, The University of Texas at Arlington

Analysis of Residual Solvents in Pharmaceutical Excipients and Products by GC-VUV

“VUV spectroscopy adds a dimension that is complementary to mass spectrometry, offering selectivity that is difficult to otherwise obtain.”

“One of the main advantages of VUV detection for us appeared to be the ability to gain more specific molecular information…co-elutions that we know exist but cannot be identified with FID can be unraveled.”

“The VUV detector will be used as a universal, calibration-free tool that provides the relative quantitative values of distinct molecules in mixtures in a rapid manner.”

“One thing that I really like about VUV is that it can be considered a universal detector but with the advantage of being familiar to us. We all used UV spectrometers in school.”

“Eliminates ionization inefficiencies that are encountered in mass spectrometry analysis."

“An amazingly simple concept extended into a powerful spectral region."

“The VUV detector is a powerful new tool in the GC toolbox."

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