GC – VUV Absorbance Spectroscopy for Quantitative Water Determination
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This article in the Feb 2017 edition of The Column describes the results of a pilot study focused on trace water determination in common organic solvents using an ionic liquid stationary phase of GC column in a GC-VUV platform.
The water content of organic solvents is one of the crucial properties that affect the quality of the products and the efficiency of the manufacturing processes. In many organic solvents, water is generally considered an impurity, and therefore its measurement in solvents is of importance for many industries and technologies. This is especially true, for...
Mutagenic impurities, such as nitrosamines are thought to cause DNA mutations, potentially leading to cancer. Since 2018 there has been a concerted effort by various regulatory bodies i ncluding the ICH and FDA to regulate the average daily intake of nitrosamines in a wide range of drug products. This a dded scrutiny has resulted in...