Gas Chromatography with Vacuum Ultraviolet Detection for Pharmaceutical Analysis

LCGC

This Dedicated Dialogue interview with Jinjian Zheng of Merck, Inc. provides his perspective on the application of GC-VUV capabilities in pharmaceutical analysis. The adoption of GC-VUV in the pharmaceutical industry will grow as it is used for, "...development of methods for impurity profiling, stability indicating, and the analysis of complex reaction mixtures."

TRACE LEVEL ANALYSIS OF NDMA USING GAS CHROMATOGRAPHY AND THE LUMA™ MULTI-CHANNEL VACUUM ULTRAVIOLET (VUV) DETECTOR

Mutagenic impurities, such as nitrosamines are thought to cause DNA mutations, potentially leading to cancer. Since 2018 there has been a concerted effort by various regulatory bodies i ncluding the ICH and FDA to regulate the average daily intake of nitrosamines in a wide range of drug products. This a dded scrutiny has resulted in...

Fast Residual Solvent Analysis by GC-VUV

Lindsey Shear-Laude, VUV Analytics

Lindsey Shear-Laude describes residual solvent analysis in pharmaceutical products by GC-VUV and static headspace. GC run times are reduced by >5X and solvent classes can be combined into individual GC runs.